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Key Documents

SAB4501477

Sigma-Aldrich

Anti-5-HT-2C antibody produced in rabbit

affinity isolated antibody

Synonym(s):

5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 2C, Serotonin receptor 2C

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P28335

UniProt accession no.

P28335

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HTR2C(3358)

General description

5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) receptor is a seven transmembrane domain protein. It is located on human chromosome Xq22-23.
Anti-5-HT-2C antibody detects endogenous levels of total 5-HT-2C protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human 5-HT-2C.

Immunogen Range: 161-210

Biochem/physiol Actions

In the nervous system, 5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) participates in coordinating the intracellular responses to serotonin. It plays a major role in the modulation of energy homeostasis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Xu Y, et al.
Neuron, 60(4), 582-589 (2008)
Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows
Quilter CR, et al.
BMC Neuroscience (2012)
Rajat K Das et al.
Respiratory physiology & neurobiology, 260, 105-113 (2018-11-18)
Hypoglossal (XII) motoneurons are activated by type 2 receptors for serotonin (5-HT). This activation is especially strong during wakefulness which facilitates diverse motor functions of the tongue, including the maintenance of upper airway patency in obstructive sleep apnea (OSA) patients.
Katsura Nozawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3408-3413 (2009-02-13)
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and extrinsic nerves, which results in various physiological
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of

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