SAB4200450

Anti-SOX11 (C-terminal) antibody produced in rabbit

IgG fraction of antiserum

• Synonym(s): Anti-SRY (sex determining region Y)-box 11
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human
• technique(s): immunohistochemistry: 1:100-1:200 using formalin-fixed paraffin-embedded rat brain and cerebellum.; indirect immunofluorescence: 1:100-1:200 using human HeLa cells.; western blot: 1:4000-1:8000 using whole extracts of HEK-293T cells overexpressing human recombinant SOX11
• UniProt accession no.: P35716
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SOX11(6664)

Description

General description

Sex determining region Y (SRY)-box 11 (SOX11) protein belongs to the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is localized in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is located on the human chromosome 2p25.2.

Specificity

Anti-SOX11 (C-terminal) recognizes human and rat SOX11.

Immunogen

peptide corresponding to the C-terminal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey, bovine and pig and differs by a single amino acid in mouse and rat.

Application

Anti-SOX11 (C-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

Biochem/physiol Actions

Sex determining region Y (SRY)-box 11 (SOX11) plays a role in the regulation of tissue remodeling during embryogenesis which is essential for neurogenesis. This protein is also involved in tumorigenesis. SOX11 protein also plays a role in the determination of cell fate. Upregulation of the SOX11 gene leads to ovarian cancer, brain tumor, medulloblastomas and gliomas. This protein functions as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL).

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable