SAB3500604

Anti-KLOTHO antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-KL
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: predicted mol wt 111 kDa
• species reactivity: human, mouse, rat
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_004786
• UniProt accession no.: Q9UEF7
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... KL(9365)

Description

General description

The gene KL (klotho) encodes a protein that has homology to β-glucosidase enzymes. The gene is mapped to human chromosome 13q12. The gene transcript spans a length of 5.2kb. Alternative splicing leads to the generation of two forms, a transmembrane and a secreted form. The transmembrane protein contains 1014 amino acids.

Immunogen

KLOTHO antibody was raised against a 16 amino acid peptide near the center of human KLOTHO.

Application

Anti-KL antibody produced in rabbit has been used as a primary antibody in immunoblot technique.

Biochem/physiol Actions

The KL (klotho) gene is also referred to as an anti-aging gene as it encodes a senescence-related molecule. It regulates fibroblast growth factor (FGF) 23 signaling by functioning as a cofactor or coreceptor. It is involved in the activation of TRPV5 (transient receptor potential cation channel subfamily V member 5), an ion channel, by functioning as a glucuronidase. Klotho affects several intracellular signaling pathways, such as p53/p21, cAMP, protein kinase C (PKC) and Wnt signaling pathways. Mutations in this gene have been associated with premature aging-like phenotypes and shortened life span. Single nucleotide polymorphisms in this gene have been associated with priapism in sickle cell anaemia.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500604.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable