SAB3500023
Anti-α-Tubulin from chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-LIS3, Anti-TUBA1A, Anti-TUBA3, Anti-Tubulin alpha-1A
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About This Item
Recommended Products
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBA1A(7846)
General description
Tubulin α 1A (TUBA1A) is a member of α-tubulin gene family. It is encoded by the gene mapped to human chromosome 12q13.12. Tubulin α 1A is a vital structural subunit of microtubules that are temporarily expressed in almost all post-mitotic neurons during neuronal development. The encoded protein structure contains a core of two β-sheets enclosed by α-helices. TUBA1A is characterized with an amino-terminal domain having guanine nucleotide-binding region, an intermediate domain and a carboxy-terminal domain.
Immunogen
Tubulin antibody was raised against a 16 amino acid peptide near the amino terminus of human Tubulin.
Application
Anti-α-tubulin from chicken has been used for Western blotting and immunohistochemistry.
Biochem/physiol Actions
Gene mutation of tubulin α-1A (TUBA1A) is observed in perisylvian asymmetrical polymicrogyria, polymicrogyria-like cortical dysplasia, and microlissencephaly in fetal cases. Alteration in the expression of the gene impairs neural migration and causes lissencephaly (LIS).
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500023.
Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Neuromuscular study of early branching Diuronotus aspetos (Paucitubulatina) yields insights into the evolution of organs systems in Gastrotricha
Nicolas Bekkouche and Katrine Worsaae
Zoological letters, 2(21) (2016)
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.
Ahlskog JK, et.al
Molecular and Cellular Biology, 30(24), 5608-5620 (2010)
Sven Stengel et al.
British journal of haematology, 198(2), 338-348 (2022-04-26)
Aberrant activity of the phosphatidylinositol-3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR [PAM]) pathway, as well as suppressed retinoic acid signalling, contribute to enhanced proliferation and the differentiation blockade of immature myeloid cells in acute myeloid leukaemia (AML). Inhibition of
TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins.
Kumar RA, et.al
Human Molecular Genetics, 19(14), 2817-2827 (2010)
A case of TUBA1A mutation presenting with lissencephaly and Hirschsprung disease.
Hikita N
Brain & Development, 36(2), 159-162 (2014)
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