RAB0543
Human IL18 / Interleukin-18 ELISA Kit
for serum, plasma, cell culture supernatants and urine
Synonym(s):
IFN-gamma-inducing factor, IL-18, Interleukin-18
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type urine
sample type plasma
sample type serum
assay range
inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 0.5 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL18(3606)
General description
The antibody pair provided in this kit detects Human IL-18 in serum, plasma, cell culture supernatants, and urine. Interleukin-18 (IL-18) is a proinflammatory cytokine, expressed in most of the mammalian tissues including adipose, liver and skeletal muscle. It is generated as pro-IL-18 which undergoes cleavage to form a mature IL-18 possessing the signal peptide. IL-18 induces Th1 (T helper cell 1) lymphocyte action mediated by interferon-γ. It controls the metabolism of lipids and glucose. Inflammasome activation is responsible for IL-18 release, which is a significant event in response to viral infection. Increased level of IL-18 is observed in kidney and liver disease, diabetes, atherosclerosis, autoimmune disease such as rheumatoid arthritis and asthma. It is also associated with the development of renal dysfunction.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human IL18 / Interleukin-18 ELISA Kit has been used to evaluate the macrophage cytokines production in response to trans-stilbene and terphenyl compounds. It has also been used to analyze and measure IL-18 levels in the urine of chronic kidney disease patients.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry
Ulke-Lemee A, et al.
Inflammation, 41(4), 1396-1408 (2018)
Annegret Ulke-Lemée et al.
Inflammation, 41(4), 1396-1408 (2018-06-28)
Inflammation is an integral component of many diseases, including chronic kidney disease (CKD). ASC (apoptosis-associated speck-like protein containing CARD, also PYCARD) is the key inflammasome adaptor protein in the innate immune response. Since ASC specks, a macromolecular condensate of ASC
Qi Zeng et al.
Cancer immunology research, 6(5), 566-577 (2018-04-15)
Immunosuppressive myeloid-derived suppressive cells (MDSCs) are characterized by their phenotypic and functional heterogeneity. To better define their T cell-independent functions within the tumor, sorted monocytic CD14+CD11b+HLA-DRlow/- MDSCs (mMDSC) from squamous cell carcinoma patients showed upregulated caspase-1 activity, which was associated
Vaios Vasileios Kaminiotis et al.
Lipids in health and disease, 16(1), 184-184 (2017-09-28)
Atherosclerosis is a chronic inflammatory disease that is promoted, among others, by pro-inflammatory cytokines such as IL-1β and IL-18 produced by NLRP 3 inflammasome. Development of atherosclerotic lesions is also affected by leptin. Furthermore, inflammasome's action is interfered with other
Victor Edgar Fiestas Solórzano et al.
Viruses, 13(9) (2021-09-29)
The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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