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Key Documents

PRS1112

Sigma-Aldrich

Anti-CCR5 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Chemokine (C-C motif) receptor 5

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About This Item

MDL number:
MFCD01864608
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 39 kDa

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P51681

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCR5(1234)

General description

C-C motif chemokine receptor 5 (CCR5) is expressed by T lymphocytes, macrophages and monocytes. It belongs to the chemokine receptor family. The gene encoding this protein is localized on human chromosome 3p21.31.

Immunogen

a peptide corresponding to amino acids 6-20 of human CCR5.

Biochem/physiol Actions

C-C motif chemokine receptor 5 (CCR5) is a receptor for chemokine ligands-3, -4 and -5. It acts as a co-receptor for human immunodeficiency virus (HIV) entry in cells.The protein also has a role in leukocyte chemotaxis. CCR5 indirectly influence the aggregation of immune cells at the site of viral infection on mucosal surfaces. It also modulates activation of immune cells during inflammation.

Linkage

The action of this antibody can be blocked using blocking peptide SBP1112.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression cloning of new receptors used by simian and human immunodeficiency viruses
Hongkui Deng
Nature, 296-300 (1997)
The CCR5?32 (rs333) polymorphism is not a predisposing factor for severe pandemic influenza in the Brazilian admixed population
Alvino Maestri
BMC Research Notes, 8, 326-326 (2015)
A strong signature of balancing selection in the 5? cis-regulatory region of CCR5
Michael J. Bamshad
Proceedings of the National Academy of Sciences of the USA, 10539?10544-10539?10544 (2002)
CC chemokine receptor 5 ?32 polymorphism: association analysis and allele distribution among cutaneous leishmaniasis patients from Pakistan.
Sophie M
Journal of Cutaneous Pathology, 43(7), 564-570 (2016)
The expression of the chemokine receptor CCR5 in tick-borne encephalitis
Sambor Grygorczuk
Journal of Neuroinflammation, 13, 45-45 (2016)
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