Skip to Content
Merck
All Photos(1)

Documents

M0317

Sigma-Aldrich

Microsomes from Liver, Pooled

from human

Synonym(s):

Liver Microsomes

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

human

Quality Level

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

Looking for similar products? Visit Product Comparison Guide

Application

Microsomes from liver have been used to study the in vitro effect of Clinacanthus nutans leaves on the activity of cytochrome P450 3A4 and 2E1.

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans
Sukh Yen Khua
Drug metabolism and personalized therapy (2017)
Verawan Uchaipichat
Drug metabolism and pharmacokinetics, 33(1), 67-76 (2017-12-16)
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo.
Anand Joshi et al.
Cancer chemotherapy and pharmacology, 86(4), 535-545 (2020-09-20)
Carboplatin dose is calculated based on kidney function, commonly estimated with imperfect creatinine-based formulae. Iohexol is used to measure glomerular filtration rate (GFR) and allows calculation of a more appropriate carboplatin dose. To address potential concerns that iohexol administered during

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service