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I0658

Sigma-Aldrich

IC 261

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one, SU5607

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About This Item

Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
186611-52-9
Molecular Weight:
311.33
MDL number:
MFCD00118156
UNSPSC Code:
12352200
PubChem Substance ID:
24278111
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL

SMILES string

COc1cc(OC)c(\C=C2/C(=O)Nc3ccccc23)c(OC)c1

InChI

1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10-

InChI key

JBJYTZXCZDNOJW-RAXLEYEMSA-N

Gene Information

human ... CSNK1D(1453) , CSNK1E(1454)

Biochem/physiol Actions

Casein kinase 1 δ (CK1δ) and CK1 ε inhibitor.

Physical form

Product is a mixture of the Z- and E-isomers, with the predominant isomer expected to be E.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marta Vázquez-Cedeira et al.
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eLife, 10 (2021-09-30)
Lung epithelial progenitors differentiate into alveolar type 1 (AT1) and type 2 (AT2) cells. These cells form the air-blood interface and secrete surfactant, respectively, and are essential for lung maturation and function. Current protocols to derive and culture alveolar cells

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