About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
color
white
mp
212.2-214.5 °C
solubility
DMSO: >10 mg/mL
originator
Sanofi Aventis
storage temp.
room temp
SMILES string
CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O
InChI
1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
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This Item | PHR1617 | Y0000515 | Y0000516 |
---|---|---|---|
form solid | form - | form - | form - |
Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level - |
storage temp. room temp | storage temp. 2-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
solubility DMSO: >10 mg/mL | solubility - | solubility - | solubility - |
color white | color - | color - | color - |
General description
Application
- as a hypoglycemic drug to test its anti-diabetic functionality in human umbilical vein cells (HUVECs)[3]
- as a sulfonylurea ATP-sensitive potassium channel (KATP) channel inhibitor in breast cancer MDA-MB-231 cells[4]
- in glucose-stimulated insulin secretion (GSIS) assays of neonatal islet-like cell clusters (NICCs) to test its effect on insulin secretion[5]
Biochem/physiol Actions
Features and Benefits
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
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Articles
Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.
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