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Key Documents

A1472

Sigma-Aldrich

MCA-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676-DNP-Lys-Arg-Arg-NH2

≥90% (HPLC)

Synonym(s):

7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676(2,4-dinitrophenyl)Lys-Arg-Arg amide

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About This Item

Empirical Formula (Hill Notation):
C86H125N27O29
Molecular Weight:
2001.08
MDL number:
MFCD03454237
UNSPSC Code:
12352202
NACRES:
NA.32

Quality Level

100

Assay

≥90% (HPLC)

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

Gene Information

human ... APP(351)

Amino Acid Sequence

MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-DNP-Lys-Arg-Arg-NH2

Application

7-Methoxycoumarin-4-acetyl-[Asn⁶⁷⁰,Leu⁶⁷¹]-Amyloid β has been used as a fluorogenic substrate to measure β-secretase activity.

Biochem/physiol Actions

Fluorescent peptide substrate containing the ′Swedish′ Lys-Met/Asn-Leu mutation of the amyloid presursor protein (APP) β-secretase cleavage site. May be used for assaying β-secretase-like activity of thimet oligopeptidase (TOP), EC 3.4.24.15.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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