90190
Transferrin from human blood plasma
≥95% (GE)
Synonym(s):
Human transferrin, Siderophilin
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About This Item
Recommended Products
biological source
human plasma
Quality Level
Assay
≥95% (GE)
form
powder or crystals
mol wt
Mr ~79550
technique(s)
tissue culture: suitable
impurities
≤0.01% iron traces (AAS)
solubility
H2O: 50 mg/mL, clear, colorless to faintly yellow or pink
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... TF(7018)
Application
Transferrin is an important supplement in serum-free tissue culture media.
Biochem/physiol Actions
Transferrin is glycoprotein, approx. 80 kDa, with two binding sites for iron. It transports iron from its primary store in the liver to tissues that require iron, primarily bone marrow and spleen, but also brain. It binds Fe3+ extremely tightly (Kdiss 10-30 to 10-27), protecting against oxidant effects of free plasma iron.
Other Notes
Review: Iron transport and storage
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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B. Gorinsky
Adv. Red Blood Cell Biol., D.J. Weatherall et al., eds., 7-7 (1981)
U R Goonetilleke et al.
mBio, 3(2) (2012-03-15)
Pneumococcal meningitis can lead to death or serious neurological sequelae as a result of the host inflammatory response. We investigated the association between host response protein expression and outcome in patients with pneumococcal meningitis. Cerebrospinal fluid (CSF) was obtained from
Iron transport and storage.
R R Crichton et al.
European journal of biochemistry, 164(3), 485-506 (1987-05-04)
Melissa Pynnonen et al.
PLoS pathogens, 7(7), e1002104-e1002104 (2011-07-14)
Staphylococcus aureus nasal colonization is an important risk factor for community and nosocomial infection. Despite the importance of S. aureus to human health, molecular mechanisms and host factors influencing nasal colonization are not well understood. To identify host factors contributing
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