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S6814

Sigma-Aldrich

SynaptoGreen™ C4

≥95% purity (HPLC), solid

Synonym(s):

FM1-43, N-(3-triethylammoniumpropyl) -4-(4-(dibutylamino)styryl) pyridinium dibromide, Pyridinium, 4-[2-[4-(dibutylamino)phenyl]ethenyl]- 1-[3-(triethylammonio)propyl]- , dibromide

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About This Item

Empirical Formula (Hill Notation):
C30H49Br2N3
CAS Number:
149838-22-2
Molecular Weight:
611.54
MDL number:
MFCD00467815
UNSPSC Code:
12171500
PubChem Substance ID:
329824569
NACRES:
NA.47

product name

SynaptoGreen™ C4, ≥95% (HPLC), solid

Quality Level

100

Assay

≥95% (HPLC)

form

solid

color

dark red

solubility

DMSO: soluble
H2O: soluble

εmax

≥50000 at 507-513 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

SMILES string

[Br-].[Br-].CCCCN(CCCC)c1ccc(\C=C\c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1

InChI

1S/C30H49N3.2BrH/c1-6-11-23-32(24-12-7-2)30-18-16-28(17-19-30)14-15-29-20-25-31(26-21-29)22-13-27-33(8-3,9-4)10-5;;/h14-21,25-26H,6-13,22-24,27H2,1-5H3;2*1H/q+2;;/p-2

InChI key

VZUVCAGXYLMFEC-UHFFFAOYSA-L

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General description

SynaptoGreen™ C4 is an oxonol dye that helps in the rapid detection of an antibiotic′s effect on bacterial viability. It is a fluorescent dye that is used in optical imaging studies to determine synaptic activity by staining synaptic vesicles at the nerve terminal or the neuromuscular junction. It is equivalent to FM1-43.

Application

SynaptoGreen™ C4 has been used to label cultured neurons grown on EM grids for fluorescent labeling, live light microscopy and imaging studies.

Biochem/physiol Actions

A fluorescent nerve terminal dye suitable for monitoring synaptic activity at synapses and at neuromuscular junctions.

Other Notes

Component of NTSI, also sold individually.

Legal Information

SynaptoGreen is a trademark of Biotium, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ0878
MKCK9991
MKCK5858
MKCK3521
MKCJ5448

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Yalda Moayedi et al.
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Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2275-2280 (2015-02-04)
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Tam H Nguyen et al.
PloS one, 7(5), e36913-e36913 (2012-05-26)
Bulk endocytosis contributes to the maintenance of neurotransmission at the amphibian neuromuscular junction by regenerating synaptic vesicles. How nerve terminals internalize adequate portions of the presynaptic membrane when bulk endocytosis is initiated before the end of a sustained stimulation is
Christopher R Heier et al.
EMBO molecular medicine, 5(10), 1569-1585 (2013-09-10)
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