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Key Documents

572636

Sigma-Aldrich

SU6656

InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases

Synonym(s):

InSolution SU6656

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About This Item

Empirical Formula (Hill Notation):
C19H21N3O3S
Molecular Weight:
371.45
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

2-8°C

General description

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC50 >10 µM) and IGF-1 receptor kinase (IC50 gt;20 µM).

Biochem/physiol Actions

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 280 nM inhibiting Src

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point(C)

87 °C - closed cup - (Dimethylsulfoxide)


Certificates of Analysis (COA)

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