341283

Factor P, Human

Factor P, Human, is a native glycoprotein found in di-, tri-, and tetrameric form (92, 138 & 184 kDa). Accelerates complement activation by binding to and stabilizing the C3 and C5 convertases.

• Synonym(s): Properdin
• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• impurities: IgG, IgA, IgM, Factor I, Factor B, Factor H, C3, C4, or albumin, trace (Ouchterlony)
• shipped in: wet ice
• storage temp.: −70°C

Description

General description

Native factor P from human serum. Glycoprotein found in blood plasma in dimeric, trimeric, and tetrameric forms with M.W. of 92 kDa, 138 kDa, and 184 kDa, respectively. Present in normal human serum at about 20 µg/ml. Regulatory protein of the alternative pathway of complement activation. Accelerates complement activation by binding to and stabilizing the alternative pathway C3 and C5 convertase enzymes.

Native factor P from human serum. Glycoprotein found in circulating blood plasma in dimeric, trimeric, and tetrameric forms with M.W. of ~92 kDa, ~138 kDa, and ~184 kDa, respectively. Present in normal human serum at about 20 µg/ml. Regulatory protein of the alternative pathway of complement activation. Accelerates complement activation by binding to and stabilizing the alternative pathway C3 and C5 convertase enzymes.

Warning

Toxicity: Standard Handling (A)

Physical form

In PBS, pH 7.2.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Pangburn, M.K., et al. 1988. Methods Enzymol. 162, 639.
Smith, C.A., et al. 1984. J. Biol. Chem. 259, 4582.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable