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860052P

Avanti

Ceramide (Brain)

Ceramide (Brain, Porcine), powder

Synonym(s):

C18 Ceramide; N-octadecanoyl-D-erythro-sphingosine; N-(octadecanoyl)-sphing-4-enine

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About This Item

CAS Number:
497156-25-9
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 200 mg (860052P-200mg)
pkg of 1 × 25 mg (860052P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860052P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1

InChI key

VODZWWMEJITOND-NXCSZAMKSA-N

General description

Ceramides comprise sphingoid base attached to fatty acyl chain by an amide bond. They vary in length, saturation and hydroxylation of the fatty acid chain and sphingoid base. Ceramides are synthesized by sphingomyelinase in salvage and de novo synthesis pathway. In brain, ceramide synthases mediate the synthesis of ceramides.

Application

Ceramide (Brain) has been used as a lipid standard
  • in ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS)
  • in liquid chromatography with a hydrophilic interaction column
  • in liposome preparation to test it effect on human α–synuclein aggregation

Biochem/physiol Actions

Ceramides are signaling molecules which play a key role in cellular events. Ceramides promote β-amyloid synthesis and induce neuronal death. Ceramide levels are associated with pathogenesis of many disease states. Impairment of ceramide metabolism is implicated in Parkinson′s and Alzheimer′s disease. High levels of ceramide is also associated with depression.

Packaging

5 mL Amber Glass Screw Cap Vial (860052P-200mg)
5 mL Amber Glass Screw Cap Vial (860052P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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James P Madigan et al.
Experimental cell research, 388(2), 111860-111860 (2020-01-24)
There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have
Ceramide and its related neurochemical networks as targets for some brain disorder therapies
Brodowicz J, et al.
Neurotoxicity Research, 33(2), 474-484 (2018)
Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
Barrier L, et al.
International Journal of Alzheimer's Disease, 2011 (2011)
Astrocytic ceramide as possible indicator of neuroinflammation
de Wit NM, et al.
Journal of Neuroinflammation, 16(1), 48-48 (2019)
Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics
Hines K M, et al.
Journal of Lipid Research, 58(4), 809-819 (2017)
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