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791644C

Avanti

18:1-d7 Lyso PE

Avanti Research™ - A Croda Brand 791644C

Synonym(s):

1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphoethanolamine

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About This Item

Empirical Formula (Hill Notation):
C23H39D7NO7P
CAS Number:
2260669-47-2
Molecular Weight:
486.63
UNSPSC Code:
41141825
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (791644C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 791644C

concentration

1 mg/mL (791644C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

18:1-d7 Lyso PE (1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphoethanolamine) is a deuterated phospholipid. The glycerol is esterified with oleic acid. Oleic acid harbors the deuterium ions. Lysophosphatidylethanolamine (LPE) is generated from phosphatidylethanolamine by the action of enzyme phospholipase A2.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.

Application

18:1-d7 Lyso PE (1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphoethanolamine) has been used as a component of extraction solvent for lipid isolation from biological samples. It has also been used as an isotopically labeled lipid internal standard for correction of lipids detected in lipid droplets using shotgun mass spectrometry analysis.

Biochem/physiol Actions

Lysophosphatidylethanolamine (LPE) plays a key role in neuronal differentiation in PC12 cells. It possesses antibacterial and antifungal activity. LPE also favour the calcium transport through G-protein-coupled receptor (GPCR).

Packaging

5 mL Clear Glass Sealed Ampule (791644C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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Caixia Ren et al.
Lipids in health and disease, 17(1), 22-22 (2018-02-06)
Migraine is a prevalent, disabling type of primary headache disorder associated with a high socioeconomic burden. The clinical management of migraine is challenging. This study was to identify potential serum lipidomic biomarkers of migraine. The serum lipidomic profile of migraine
Kumiko Makide et al.
Prostaglandins & other lipid mediators, 89(3-4), 135-139 (2009-05-12)
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using

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