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W422312

Sigma-Aldrich

Betaine

≥98%

Synonym(s):

(Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine

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About This Item

Linear Formula:
(CH3)3N+CH2COO-
CAS Number:
107-43-7
Molecular Weight:
117.15
FEMA Number:
4223
Beilstein:
3537113
MDL number:
MFCD00012123
UNSPSC Code:
12164502
NACRES:
NA.21

grade

Halal
Kosher

reg. compliance

FDA 21 CFR 117

Assay

≥98%

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

odorless

SMILES string

C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

InChI key

KWIUHFFTVRNATP-UHFFFAOYSA-N

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Application


  • Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.: Betaine is evaluated for its antimicrobial properties in a clinical setting, comparing its effectiveness with standard treatments for enhancing wound healing and preventing infection in diabetic foot ulcers. This study contributes to the optimization of therapeutic strategies for chronic wounds (Zhao J et al., 2024).

  • [Clinical features and follow-up study on 55 patients with adolescence-onset methylmalonic acidemia].: This research includes betaine in the treatment protocols for patients with methylmalonic acidemia, analyzing its effectiveness in reducing symptoms and improving metabolic profiles. The study provides valuable insights into the management of this rare metabolic disorder (Ma X et al., 2024).

Biochem/physiol Actions

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Disclaimer

For R&D or non-EU Food use. Not for retail sale.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shu Yang et al.
Journal of the science of food and agriculture, 100(4), 1486-1494 (2019-11-23)
We reported previously that maternal betaine promotes hepatic insulin-like growth factor (IGF2) expression in F1 offspring rats through hypermethylation of the IGF2/H19 imprinting control region (ICR). It remains unknown whether this acquired trait can be transmitted to the F2 generation.
Yang Yang et al.
Molecular nutrition & food research, 64(8), e1900823-e1900823 (2020-02-06)
Betaine serves as a methyl donor for DNA methylation. Here, the effects of betaine on hippocampal expression of neurogenesis genes and their DNA methylation status across three generations are investigated. Pregnant rats (F0) are fed control and betaine-supplemented diets throughout
Nannan Zhao et al.
European journal of nutrition, 59(4), 1707-1716 (2019-06-16)
Excessive exposure of glucocorticoids activates adipose lipolysis, increases circulating free fatty acids, and contributes to ectopic lipid deposition in liver and skeletal muscle. Our previous study demonstrated that maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation in rat offspring. However

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