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A7256

Sigma-Aldrich

DL-Norepinephrine hydrochloride

crystalline, ≥97% (TLC)

Synonym(s):

(±)-1-(3,4-Dihydroxyphenyl)-2-aminoethanol hydrochloride, (±)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol hydrochloride, DL-Arterenol hydrochloride, DL-Noradrenaline hydrochloride

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About This Item

Linear Formula:
(HO)2C6H3CH(OH)CH2NH2 · HCl
CAS Number:
55-27-6
Molecular Weight:
205.64
Beilstein:
3707003
EC Number:
200-229-8
MDL number:
MFCD00012880
UNSPSC Code:
12352100
PubChem Substance ID:
57653879
NACRES:
NA.22

Quality Level

200

Assay

≥97% (TLC)

form

crystalline

color

off-white to tan

solubility

water: soluble 50 mg/mL, clear to slightly hazy, faintly yellow to brownish-yellow

storage temp.

−20°C

SMILES string

NCC(C1=CC(O)=C(C=C1)O)O.Cl

InChI

1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H

InChI key

FQTFHMSZCSUVEU-UHFFFAOYSA-N

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General description

DL-Norepinephrine hydrochloride is an adrenergic drug.

Application

DL-Norepinephrine hydrochloride is suitable adrenergic drug used in the following studies:
  • To investigate the effects of adrenergic drugs on lantern of larval fly.
  • To evaluate the ability of α-adrenergic stimulation in the presence of elevated calcium levels to induce delayed after depolarizations and triggered activity in Purkinje fibers isolated from cat hearts.
  • Simultaneous reduction and surface functionalization of graphene oxide by a one-step poly(norepinephrine) functionalization.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ5284
MKCP5464
MKCL5708
MKCG2176
MKCC1425

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S Kimura et al.
Circulation, 70(6), 1074-1082 (1984-12-01)
We studied the ability of alpha-adrenergic stimulation to induce delayed afterdepolarizations and triggered activity in Purkinje fibers from cat hearts in the presence of an elevated Ca++ concentration. Delayed afterdepolarizations could not be induced at drive cycle lengths of 200
Effect of adrenergic drugs on the lantern of the larval Photuris firefly.
A D Carlson
The Journal of experimental biology, 48(2), 381-387 (1968-04-01)
Simultaneous Reduction and Surface Functionalization of Graphene Oxide by Mussel-Inspired Chemistry.
Kang SM, et al.
Advances in Functional Materials, 21(1), 108-112 (2011)
Yuki Komoto et al.
Scientific reports, 10(1), 11244-11244 (2020-07-11)
The analysis of neurotransmitters in the brain helps to understand brain functions and diagnose Parkinson's disease. Pharmacological inhibition experiments, electrophysiological measurement of action potentials, and mass analysers have been applied for this purpose; however, these techniques do not allow direct
Silvia Giatti et al.
Journal of medicinal chemistry, 64(8), 4553-4566 (2021-04-13)
Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints, suggesting that other mechanisms, in addition to 5α-R inhibition, may be involved. Here, a
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