930113

NanoFabTx^™- COOH Lipid Mix

for synthesis of carboxyl functionalized liposomes

• Synonym(s): for small molecule drug delivery
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Quality Level: 100
• storage temp.: −20°C

Description

General description

NanoFabTX^™- COOH Lipid Mix; for synthesis of carboxyl functionalized liposomes is a ready-to-use Nano formulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing carboxyl functionalized liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins and peptides. The carboxyl functionalized surface group allows for facile conjugation of targeting groups onto the liposome surface for targeted drug delivery.

Application

About NanoFabTx^™

NanoFabTx^™ is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx^™ provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Features and Benefits

• A ready-to-use Nano formulation lipid blend for the synthesis of carboxyl functionalized liposomes
• Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
• Flexible synthesis tool to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• Carboxyl surface functionalization allows for targeting ligand conjugation to enable targeted drug delivery

The NanoFabTX^™- COOH Lipid Mix provides lipid blends and protocols for extrusion and microfluidics to synthesize liposomes for drug delivery research application. This lipid mix can be combined with the NanoFabTx^™ Microfluidic - Nano device kit (Cat.No. 911593) for microfluidic synthesis of carboxyl functionalized liposomes.

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol
• A microfluidics protocol using commercial platforms or syringe pumps

The microfluidics protocol included with this product uses the NanoFabTx^™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the document section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3