928380

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid

≥95%

• Empirical Formula (Hill Notation): C₁₈H₂₉N₅O₅
• Molecular Weight: 395.45
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: Boc; amine; carboxylic acid
• storage temp.: 2-8°C

Description

Application

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.

Other Notes

Technology Article: Degrader Building Blocks for Targeted Protein Degradation


Building PROTAC^® Degraders for Targeted Protein Degradation


Crosslinkers for Bioconjugation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable