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923834

Sigma-Aldrich

Chitosan-mPEG 1k

25-60% PEGylation, medium MW

Synonym(s):

Medium MW, PEGylated Chitosan

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About This Item

Linear Formula:
(C8H13NO5)p((C2H4O)nC10H17NO6)m
UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

form

solid (powder or chunk(s) or fiber)

color

white to off-white

storage temp.

2-8°C

Application

  • Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
  • Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
  • During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Peggy Chan et al.
Biomaterials, 28(3), 540-549 (2006-09-27)
Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing
Li Xiang et al.
Physical chemistry chemical physics : PCCP, 21(37), 20571-20581 (2019-08-01)
PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan

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