707929

4-Isoquinolineboronic acid

• Synonym(s): Isoquinolin-4-ylboronic acid, Isoquinoline-4-boronic acid
• Empirical Formula (Hill Notation): C₉H₈BNO₂
• CAS Number: 192182-56-2
• Molecular Weight: 172.98
• MDL number: MFCD03412093
• UNSPSC Code: 12352103
• PubChem Substance ID: 329762755

Properties

• form: solid
• mp: 230-234 °C
• storage temp.: 2-8°C
• SMILES string: OB(O)c1cncc2ccccc12
• InChI: 1S/C9H8BNO2/c12-10(13)9-6-11-5-7-3-1-2-4-8(7)9/h1-6,12-13H
• InChI key: GDTOUTKTCGPAGY-UHFFFAOYSA-N

Description

General description

May contain varying amounts of anhydride

Application

Reactant for:

• Preparation of selective steroid-11β-hydroxylase (CYP11B1) inhibitors for treatment of cortisol dependent diseases
• Preparation of tetrabutylammonium trifluoroborates
• Preparation of heteroaryl substituted tetrahydropyrroloijquinolinone derivatives as aldosterone synthase inhibitors
• Synthesis of aminoarylpyridazines as selective CB2 agonists for treatment of inflammatory pain
• Preparation of acyl substituted indoles via palladium-catalyzed domino coupling/carbonylation/Suzuki coupling of dibromoethenylanilines
• Synthesis of antagonists of bacterial quorum sensing
• Preparation of potassium heteroaryl trifluoroborates from boronic acids and their use as coupling partners with various aryl and heteroaryl halides in Suzuki-Miyaura cross-coupling reactions

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves