496065

2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine

98%

• Synonym(s): (R,R)-2,6-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine, (R,R)-2,6-Bis(4-phenyl-2-oxazolinyl)pyridine
• Empirical Formula (Hill Notation): C₂₃H₁₉N₃O₂
• CAS Number: 128249-70-7
• Molecular Weight: 369.42
• MDL number: MFCD01863585
• UNSPSC Code: 12352005
• PubChem Substance ID: 24873016
• NACRES: NA.22

Properties

• Assay: 98%
• optical activity: [α]22/D 187°, c = 1 in methylene chloride
• mp: 171-175 °C (lit.)
• SMILES string: C1OC(=N[C@@H]1c2ccccc2)c3cccc(n3)C4=N[C@@H](CO4)c5ccccc5
• InChI: 1S/C23H19N3O2/c1-3-8-16(9-4-1)20-14-27-22(25-20)18-12-7-13-19(24-18)23-26-21(15-28-23)17-10-5-2-6-11-17/h1-13,20-21H,14-15H2/t20-,21-/m0/s1
• InChI key: HLHBIMJNCKZZQO-SFTDATJTSA-N

Description

Application

2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine [Pybox] may be used as a chiral ligand in the copper-catalyzed enatioselective arylation of N-arylated tetrahydroisoquinolines (THIQs) with arylboronic acids in the presence of a photoredox catalyst.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves