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Merck

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonyms:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Species:
UniProtKB ID:
Gene ID:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Felodipine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Nimodipine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Blocker

Product Number
Description
Species
Margatoxin, ,
Species
mouse, rat, human
Nicardipine hydrochloride, powder, ≥98%,
Species
human
(±)-Verapamil hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Nifedipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Nifedipine, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA1D,
Species
human