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A horizontal process drives the flow of work. Horizontal processes are necessary to link all vertical processes into a coherent system.
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A horizontal process drives the flow of work. Horizontal processes are necessary to link all vertical processes into a coherent system.
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A horizontal process drives the flow of work. Horizontal processes are necessary to link all vertical processes into a coherent system.
Workflow
Sample Collection
A horizontal process drives the flow of work. Horizontal processes are necessary to link all vertical processes into a coherent system.
Standardization & Calibration
A horizontal process drives the flow of work. Horizontal processes are necessary to link all vertical processes into a coherent system.
Related Articles
- Carbonyl compounds react within the DNPH cartridge to form immobilized hydrazones, which can be subjected to automated desorption and HPLC analysis with UV detection.
- Various plastics used as barriers to the production of off-flavors in light exposed milk were examined using HS-SPME with a new Carboxen®/PDMS coated Nitinol fiber followed by GC-MS analysis allowing detection of low MW analytes at levels <1 ng/mL.
- The odor and pungency of ginger is due to the presence of terpenes, gingerols and shogaols. These compounds contribute to the highly complex matrix of ginger, which subsequently presents a challenge in low level analyses of contaminants. A novel 2-layer SPE cartridge efficiently reduces background for pesticide determination.
- Pistachios contain approximately 45% fat, which can result in a significant amount of coextracted matrix in the acetonitrile extract generated using the QuEChERS procedure. A zirconia based adsorbent significantly reduces coextracted matrix prior to LC-MS or GC-MS.
- This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.
- This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.
- This article validates the ability to perform cleanup of urine samples using HLB solid-phase extraction (SPE) for the analysis of opioids via tandem mass spectrometry (LC-MS/MS) after cleanup with the Supel™ Swift HLB 96-well plate.
- Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples utilizing chiral and achiral (reversed-phase) chromatography and effective sample prep to remove endogenous phospholipids.
Related Protocols
- Fast, high-resolution separations of procainamide labeled glycans - dextran ladder, human IgG and cetuximab
- In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.
- Optimized sample prep and chiral chromatography methods for the LC/MS analysis of these drug enantiomers in urine
- To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.
- THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; Cannabidiolic acid solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Cannabichromene solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; Cannabigerolic acid solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Δ9-Tetrahydrocannabinolic acid A (THCA-A)
- A 100 mg sample of dried cannabis sativa leaves was extracted with 50 mL of ethanol:water (50:50, v/v) for 15 mins in an ultrasonic bath.
- Acrylamide analysis has been a very hot topic since the chemical was identified in food in 2002 by researchers at the Swedish National Food Administration.
- SupelMIP SPE-Bisphenol A gave high recovery for baseline resolution of five related compounds with LC-Fluorescence detection.
References
1.
Chatterjee AK, Grubbs RH. 1999. Synthesis of Trisubstituted Alkenes via Olefin Cross-Metathesis. Org. Lett.. 1(11):1751-1753. https://doi.org/10.1021/ol991023p
2.
Stewart IC, Ung T, Pletnev AA, Berlin JM, Grubbs RH, Schrodi Y. 2007. Highly Efficient Ruthenium Catalysts for the Formation of Tetrasubstituted Olefins via Ring-Closing Metathesis. Org. Lett.. 9(8):1589-1592. https://doi.org/10.1021/ol0705144
3.
Benitez D, Goddard WA. 2005. The Isomerization Equilibrium between Cis and Trans Chloride Ruthenium Olefin Metathesis Catalysts from Quantum Mechanics Calculations. J. Am. Chem. Soc.. 127(35):12218-12219. https://doi.org/10.1021/ja051796a
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