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408719

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~800 by LS, average Mn ~600 by GPC

Synonym(s):

PEI, ethylenediamine branched

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About This Item

Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
25987-06-8
MDL number:
MFCD00084427
UNSPSC Code:
12162002
NACRES:
NA.23

form

viscous liquid

Quality Level

200

mol wt

average Mn ~600 by GPC
average Mw ~800 by LS

refractive index

n20/D 1.5240

density

1.050 g/mL at 25 °C

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI key

SFLOAOINZSFFAE-UHFFFAOYSA-N

Related Categories

General description

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO2 adsorbent. Numerous amino groups present in PEI can react with CO2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Features and Benefits

  • Branched PEI has better complexation and buffering capacity.
  • High ion exchange capacity and affinity toward proteins.
  • SignificantDNA transfer efficiency.

Physical form

Branched polymer

Signal Word

Danger

Hazard Statements

H302 - H318 - H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

356.0 °F

Flash Point(C)

180 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Articles

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Polyelectrolyte Multilayer Films and Membrane Functionalization

We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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