SLC46A1
solute carrier family 46 (folate transporter), member 1
Synonyms:
G21, HCP1, PCFT
Species:
Human SLC46A1 (113235), Mouse Slc46a1 (52466), Rat Slc46a1 (303333), Zebrafish slc46a1 (393255), Horse SLC46A1 (100072047), domestic cat SLC46A1 (101100096), chicken SLC46A1 (417569), dog SLC46A1 (491166), cow SLC46A1 (511097), sheep SLC46A1 (101119738) ...More
UniProtKB ID:
Gene ID:
- Human(113235) Summary: This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
- Mouse(52466) solute carrier family 46, member 1
- Rat(303333) solute carrier family 46 (folate transporter), member 1
- Zebrafish(393255) solute carrier family 46, member 1
- Horse(100072047) solute carrier family 46 (folate transporter), member 1
- domestic cat(101100096) solute carrier family 46 (folate transporter), member 1
- chicken(417569) solute carrier family 46 (folate transporter), member 1
- dog(491166) solute carrier family 46 (folate transporter), member 1
- cow(511097) solute carrier family 46 (folate transporter), member 1
- sheep(101119738) solute carrier family 46 (folate transporter), member 1
- naked mole-rat(101706680) solute carrier family 46 (folate transporter), member 1
- domestic guinea pig(100726936) solute carrier family 46 (folate transporter), member 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SLC46A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
esiRNA
Product Number
Description
Species