- Total synthesis of clavilactone B: a radical cyclization-fragmentation strategy.
Total synthesis of clavilactone B: a radical cyclization-fragmentation strategy.
Organic letters (2014-12-17)
Hiroshi Suizu, Daisuke Shigeoka, Hiroshi Aoyama, Takehiko Yoshimitsu
PMID25513832
ABSTRACT
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
MATERIALS
Product Number
Brand
Product Description
Samarium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%
Samarium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%
Samarium, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%
Samarium, rod, 100mm, diameter 6.35mm, cast, 99%
Samarium, rod, 50mm, diameter 6.35mm, cast, 99%