Cobalt: its role in health and disease.

Cobalt: its role in health and disease.

Metal ions in life sciences (2014-01-29)

Kazuhiro Yamada

ABSTRACT

The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of cobalt in human health. Cbl acts as the cofactor for two enzymes, i.e., methylmalonyl-CoA mutase and methionine synthase, in humans. Both enzymes are important for health. In addition, unlike other water-soluble vitamins, there is a unique absorption, delivery, and activation system for Cbl in mammals. Therefore, this chapter will also review the literature on the Cbl transporting system, which is crucial for Cbl function.

MATERIALS

Product Number

Brand

Product Description

203076

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

398810

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

356891

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

356867

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

GF64744937

Cobalt, foil, not light tested, 100x100mm, thickness 0.05mm, as rolled, 99.99+%

GF44846208

Cobalt, foil, not light tested, 150x150mm, thickness 0.015mm, 99.9%

GF46475220

Cobalt, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.9%

GF88007564

Cobalt, foil, not light tested, 50x50mm, thickness 0.02mm, 99.9%

GF45144985

Cobalt, foil, not light tested, 100x100mm, thickness 0.007mm, 99.9%

GF94203503

Cobalt, foil, not light tested, 25x25mm, thickness 0.003mm, 99.9%

GF72081592

Cobalt, foil, light tested, 50x50mm, thickness 0.025mm, 99.9%

GF06922920

Cobalt, foil, 8mm disks, thickness 0.009mm, 99.9%

GF15841199

Cobalt, foil, 6mm disks, thickness 0.008mm, 99.9%

GF00561204

Cobalt, foil, not light tested, 50x50mm, thickness 0.002mm, temporary acrylic support, 99.9%

GF56754557

Cobalt, foil, not light tested, 100x100mm, thickness 0.025mm, 99.9%

GF53589897

Cobalt, foil, light tested, 25x25mm, thickness 0.015mm, 99.9%

GF91382069

Cobalt, wire reel, 0.1m, diameter 0.1mm, hard, 99.99+%

GF93295299

Cobalt, foil, not light tested, 25x25mm, thickness 0.004mm, 99.9%

GF16350599

Cobalt, foil, light tested, 50x50mm, thickness 0.02mm, 99.9%

GF95862134

Cobalt, microfoil, disks, 25mm, thinness 0.25μm, specific density 222μg/cm², permanent mylar 3.5μm support, 99.9%

GF94218666

Cobalt, foil, not light tested, 25x25mm, thickness 0.009mm, 99.9%

GF60120997

Cobalt, wire reel, 0.05m, diameter 0.5mm, hard, 99.99+%

GF17951160

Cobalt, foil, not light tested, 50x50mm, thickness 0.003mm, 99.9%

GF13124146

Cobalt, foil, not light tested, 100x100mm, thickness 0.02mm, 99.9%

GF15401135

Cobalt, foil, light tested, 25x25mm, thickness 0.01mm, 99.9%

GF04563187

Cobalt, wire reel, 0.1m, diameter 0.25mm, hard, 99.99+%

GF00377029

Cobalt, foil, not light tested, 50x50mm, thickness 0.0125mm, 99.9%

GF40673707

Cobalt, foil, not light tested, 25x25mm, thickness 0.005mm, 99.9%