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Benzoquinolinediones: activity as insect teratogens.

Science (New York, N.Y.) (1983-10-28)
B T Walton, C Ho, C Y Ma, E G O'Neill, G L Kao
ABSTRACT

Morphological abnormalities including extra compound eyes, extra heads, and distally duplicated legs were generated in cricket embryos by treating eggs with single doses of either benz[g]isoquinoline-5,10-dione or benzo[h]quinoline-5,6-dione. Slight structural modifications of the molecules resulted in a loss of teratogenic activity, although embryotoxicity occurred. These potent insect teratogens can be used for analysis of developmental events during embryogenesis.

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Benz[g]isoquinoline-5,10-dione, 99%
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