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  • Urinary metabolites of chloroprocaine studied by combined gas chromatography--mass spectrometry.

Urinary metabolites of chloroprocaine studied by combined gas chromatography--mass spectrometry.

Anesthesiology (1981-04-01)
K Krohg, E Jellum
ABSTRACT

The purpose of this study was to identify the metabolic pathway of 2-chloro-4-aminobenzoic acid (CABA), a primary metabolite of chloroprocaine. Urine was collected from 4 healthy, pregnant women following the epidural administration of 600 mg chloroprocaine. The urinary metabolites were extracted with ether and identified and quantitatively estimated with a gas chromatography--mass spectrometry instrument. The analysis showed that CABA is converted to N-acetyl-CABA and subsequently excreted in the urine.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Amino-2-chlorobenzoic acid, 97%
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