Skip to Content
Merck
  • Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata.

Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata.

Molecules (Basel, Switzerland) (2012-08-01)
Norhayati Muhammad, Laily B Din, Idin Sahidin, Siti Farah Hashim, Nazlina Ibrahim, Zuriati Zakaria, Wan A Yaacob
ABSTRACT

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC₅₀s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC₅₀s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC₅₀ values between 161 to 830 µM.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, purum, ≥99.0% (GC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, tested according to Ph. Eur.
SKU
Pack Size
Availability
Price
Quantity
Supelco
3,5-Di-tert-butyl-4-hydroxytoluene, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Butylhydroxytoluene, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Butylated hydroxytoluene, ≥99%, FCC, FG
SKU
Pack Size
Availability
Price
Quantity
Supelco
Butylated Hydroxytoluene, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity