SRP6330
CD46 human
recombinant, expressed in E. coli, ≥85% (SDS-PAGE)
Synonym(s):
AHUS2, MCP, MIC10, Membrane cofactor protein isoform 14, TLX, TRA2.10
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
Assay
≥85% (SDS-PAGE)
form
liquid
mol wt
33.8 kDa (302 aa, 35-313 aa + His tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CD46(4179)
General description
Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Weixin Xiong et al.
Thrombosis and haemostasis, 117(2), 401-414 (2016-11-11)
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis
Maximilian Richter et al.
Molecular therapy. Methods & clinical development, 5, 16013-16013 (2016-04-14)
Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies. However, a large fraction of treated patients relapse with rituximab-resistant disease. So far, only modest progress has been made in
Autophagy and apoptosis induced by Chinese giant salamander (Andrias davidianus) iridovirus (CGSIV).
Jian Du et al.
Veterinary microbiology, 195, 87-95 (2016-10-25)
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding
Shao-Yeh Lu et al.
Applied and environmental microbiology, 85(11) (2019-03-25)
Microcin PDI (MccPDI), a class IIa microcin that is produced by Escherichia coli strains 25 and 284, is known to inhibit foodborne pathogenic enterohemorrhagic E. coli serotypes O157:H7 and O26. Here we demonstrate that MccPDI can inhibit Shigella strains and
Sinan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(5), 1305-1315 (2020-12-10)
We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, [89Zr]DFO-YS5, and evaluated its performance for immunoPET imaging in murine prostate cancer models. [89Zr]DFO-YS5 was prepared and its in
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