SAB5600064
Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal
recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin
Synonym(s):
phosphorylation at Ser473
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
recombinant
expressed in HEK 293 cells
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM251, monoclonal
recombinant monoclonal
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 1:1000-1:2000
immunohistochemistry: 1:200-1:500
isotype
IgG
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer473)
Gene Information
human ... AKT1(207)
General description
AKT1 (AKT serine/threonine kinase 1) is also called as v-akt murine thymoma viral oncogene homolog 1 and PKB α (protein kinase B). It is expressed in liver,muscle and adipocytes. AKT1 gene is mapped to human chromosome 14q32. It is a member of AKT family that has an amino-terminal pleckstrin homology (PH) domain, a short α helical linker and a carboxyl-terminal kinase domain.
Specificity
This antibody reacts to Akt only when phosphorylated at Ser473. There is no cross-reactivity with Akt without phosphorylation at Ser473. This antibody may also react to bovine, mouse or rat Phospho-Akt (Ser473), as predicted by immunogen homology
Immunogen
Synthetic peptide corresponding to human Phospho-Akt (Ser473)
Biochem/physiol Actions
AKT1 (AKT serine/threonine kinase 1) controls the survival of cells and anti-apoptotic actions that attack the pathogenesis of several cancers, hence it plays a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cho H, et al.
The Journal of Biological Chemistry, 276(42), 38349-38352 (2001)
AKT plays a central role in tumorigenesis
Testa JR and Bellacosa A
Proceedings of the National Academy of Sciences of the USA, 98(20), 10983-10985 (2001)
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Frontiers in cell and developmental biology, 8, 597673-597673 (2021-01-26)
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