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P2508

Sigma-Aldrich

Proflavine hemisulfate salt hydrate

powder

Synonym(s):

3,6-Diaminoacridine hemisulfate salt

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5 G
CHF 243.00

CHF 243.00

Estimated to ship onMay 12, 2025

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5 G
CHF 243.00

About This Item

Empirical Formula (Hill Notation):
C13H11N3 · 0.5 H2SO4 · xH2O
CAS Number:
1811-28-5
Molecular Weight:
258.29 (anhydrous basis)
Beilstein:
3921806
EC Number:
217-320-3
MDL number:
MFCD00149650
UNSPSC Code:
12171500
PubChem Substance ID:
24898329
NACRES:
NA.47

CHF 243.00

Estimated to ship onMay 12, 2025

Request a Bulk Order

form

powder

Quality Level

100

solubility

H2O: 10 mg/mL

fluorescence

λex 444 nm; λem 508 nm (0.01M HCl)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[H]O[H].OS(O)(=O)=O.Nc1ccc2cc3ccc(N)cc3nc2c1.Nc4ccc5cc6ccc(N)cc6nc5c4

InChI

1S/2C13H11N3.H2O4S.H2O/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h2*1-7H,14-15H2;(H2,1,2,3,4);1H2

InChI key

DTRLDKDFCPUGCA-UHFFFAOYSA-N

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1 of 4

This Item
M9163M7528M5017
Sigma-Aldrich

M0650

Medium 199

Sigma-Aldrich

M9163

Medium 199

Medium 199 HEPES Modification, with Earle′s salts, 25 mM HEPES and sodium bicarbonate, without L-glutamine, liquid, sterile-filtered, suitable for cell culture

M7528

Medium 199

Medium 199 With Earle′s salts and L-glutamine, without sodium bicarbonate, powder, suitable for cell culture

M5017

Medium 199

sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

sterility

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

components

NaHCO3: no
phenol red: yes
sodium pyruvate: no
HEPES: no
Earle’s salts (5% CO2): yes
L-glutamine: no

components

phenol red: yes
HEPES: no
sodium pyruvate: no
Hanks’ salts (2% CO2): yes
L-glutamine: no
NaHCO3: no

components

L-glutamine: no
sodium pyruvate: no
HEPES: 25 mM
phenol red: yes
NaHCO3: yes
Earle’s salts (5% CO2): yes

components

L-glutamine: yes
phenol red: yes
NaHCO3: no
sodium pyruvate: no
Earle’s salts (5% CO2): yes
HEPES: no

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Proflavine is a small, amphipathic, acridine-derived fluorescent dye.Proflavine hemisulfate is used as a rapid stain for cytological studies of biological specimens. It stains cytoplasmic structures and nuclei. Proflavine has the capability to intercalate double stranded DNA.[1]

Application

Proflavine hemisulfate salt hydrate has been used to stain cells of the 1483 cell line.[2] It has also been used as a calibrating dye in fluorescence resonance energy transfer (FRET) analysis.[3]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    SHBN8862
    SHBN0829
    SHBL5759
    MKCC6558
    MKBW3135V

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    Emma V Ainsworth et al.
    Chembiochem : a European journal of chemical biology, 17(24), 2324-2333 (2016-09-30)
    The transfer of photoenergized electrons from extracellular photosensitizers across a bacterial cell envelope to drive intracellular chemical transformations represents an attractive way to harness nature's catalytic machinery for solar-assisted chemical synthesis. In Shewanella oneidensis MR-1 (MR-1), trans-outer-membrane electron transfer is
    Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy
    M. R. Tadross
    Journal of Microscopy (2009)
    Improving spatial resolution of a fiber bundle optical biopsy system
    Matthew Kyrish
    Proceedings of SPIE (2010)
    Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology
    Sandra P. Prieto
    PLoS ONE, 10(5) (2015)
    A Orth et al.
    Science advances, 5(4), eaav1555-eaav1555 (2019-04-30)
    Optical fiber bundle microendoscopes are widely used for visualizing hard-to-reach areas of the human body. These ultrathin devices often forgo tunable focusing optics because of size constraints and are therefore limited to two-dimensional (2D) imaging modalities. Ideally, microendoscopes would record

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