F5178

Flavin-Containing Monooxygenase-5, Microsomes human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution (2.5 mg in 100 mM Potassium Phosphate Buffer)

• Synonym(s): FMO-5
• Enzyme Commission number: 1.14.13.8 (BRENDA, IUBMB)
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• recombinant: expressed in baculovirus infected insect cells
• Quality Level: 200
• form: buffered aqueous solution (2.5 mg in 100 mM Potassium Phosphate Buffer)
• specific activity: ≥700 units/mg protein
• mol wt: 55-60 kDa
• packaging: vial of 2.5 mg
• UniProt accession no.: P49326
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FMO5(2330)

Description

Application

FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Biochem/physiol Actions

FMO′s are responsible for catalyzing the oxygenation of a variety of xenobiotic and drug compounds including environmental pollutants and carcinogens, which demonstrate a nucleophilic nitrogen, sulfur, selenium, and phosphorous-containing moiety associated with their respective oxides. These enzymes are classified as Phase I or oxidative drug metabolism enzymes. FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Unit Definition

methyl p-tolyl sulfide oxidase activity: One unit will catalyze the production of 1.0 picomole of methyl p-tolyl sulfoxide.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves