ABN16
Anti-GPR56 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
G protein-coupled receptor 56, 7-transmembrane protein with no EGF-like N-terminal domains-1, Protein TM7XN1, G-protein coupled receptor 56
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
General description
G-protein coupled receptor 56 (GPR56) is a novel, multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and containing a characteristic, extracellular GPS domain. Although newly discovered, studies have suggested roles for the protein in the adhesion between developing neurons, regulating the integrity of pial basement membranes, regulating corticogenesis, and may also be involved in cancer cell metastasis and adhesion. Expression has been observed in a wide variety of peripheral tissues, but the most significant levels have been reported in brain, heart, and thyroid gland. Defects in GPR56 expression cause bilateral frontoparietal polymicrogyria (BFPP), a malformation of the brain in humans that is characterized by ataxia, seizures, disfigurement of the cerebral cortex, and mental retardation.
Specificity
This antibody recognizes GPR56 at the N-terminus.
Immunogen
Epitope: N-terminus
Linear peptide corresponding to the N-terminus sequence of mouse GPR56.
Application
Detect GPR56 using this Anti-GPR56 Antibody validated for use in IH.
Immunohistochemistry Analysis: 1:200 dilution of this antibody from a previous lot detected GPR56 in anal carcinoma and testicular teratoma tissue.
Research Category
Neuroscience
Neuroscience
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurotransmitters & Receptors
Neurodegenerative Diseases
Neurotransmitters & Receptors
Quality
Evaluated by Immunohistochemistry in inflammatory skin biopsy tissue.
Immunohistochemistry Analysis: 1:200 dilution of this antibody detected GPR56 in inflammatory skin biopsy tissue.
Immunohistochemistry Analysis: 1:200 dilution of this antibody detected GPR56 in inflammatory skin biopsy tissue.
Target description
77 kDa calculated
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.05% sodium azide with 50% Glycerol.
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Analysis Note
Control
Inflammatory skin biopsy tissue
Inflammatory skin biopsy tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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