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344273-M

Sigma-Aldrich

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride

≥92% (HPLC), solid, adenylate cyclase activator, Calbiochem®

Synonym(s):

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl

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About This Item

Empirical Formula (Hill Notation):
C29H48N2O7 · 2HCl
CAS Number:
115116-37-5
Molecular Weight:
609.62
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, Chemically-modified forskolin with greater stability and water solubility than the parent compound.

Quality Level

200

Assay

≥92% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 12 mg/mL
methanol: soluble

storage temp.

10-30°C

General description

A chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC50 = 13 µM).
Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.

Biochem/physiol Actions

EC50 = 13 µM in activating adenylate cyclase
Primary Target
Adenylate cyclase

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Other Notes

Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol.41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol.23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol.32, 133.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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