12666
Albumin, Human Serum, Fraction V, Low Heavy Metals
Synonym(s):
Albumin, Human Serum, Fraction V, Low Heavy Metals
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About This Item
Assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤5.0% Ash
≤6% moisture
pI
4.7
solubility
water: 50 mg/mL
cation traces
heavy metals: ≤20 ppm
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
General description
Human serum albumin (HSA) is an abundant protein found in the plasma. This globular, soluble, and unglycosylated monomeric protein, has three homologous domains (I, II, and III). These domains have subdomains A and B having common structural motifs. The HSA gene is located on the human chromosome 4q13.3.
Application
Albumin, Human Serum, Fraction V, Low Heavy Metals has been used:
- as a supplement in double buffer and milliQ-water for in vivo
- in serum-free media for polarized secretion assays in human dermal microvascular endothelial cells
- as a supplement in sodium phosphate buffer for the reconstitution of hormone lysis samples
Biochem/physiol Actions
Human serum albumin (HSA) is very crucial in stabilizing extracellular fluid volume. It functions as an excipient for vaccines and therapeutic protein drugs. HSA serves as a cell culture medium supplement for the synthesis of vaccines and pharmaceuticals. It is useful as a carrier protein for steroids, fatty acids, and thyroid hormones. HSA is used to treat cardiopulmonary bypass, trauma, hemorrhage, and hypoalbuminemia. HSA is useful in biological applications, such as implantable biomaterials, biochromatography, surgical adhesives, and sealants.
Warning
Toxicity: Standard Handling (A)
Preparation Note
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Tina Jorsal et al.
The Journal of clinical endocrinology and metabolism, 104(12), 6403-6416 (2019-07-06)
After Roux-en-Y gastric bypass (RYGB) surgery, postprandial plasma glucagon concentrations have been reported to increase. This occurs despite concomitant improved glucose tolerance and increased circulating plasma concentrations of insulin and the glucagon-inhibiting hormone glucagon-like peptide 1 (GLP-1). To investigate whether
Chanchal Sadhu et al.
Journal of immunology (Baltimore, Md. : 1950), 170(5), 2647-2654 (2003-02-21)
Neutrophil chemotaxis is a critical component of the innate immune response. Neutrophils can sense an extremely shallow gradient of chemoattractants and produce relatively robust chemotactic behavior. This directional migration requires cell polarization with actin polymerization occurring predominantly in the leading
Nicolai J Wewer Albrechtsen et al.
American journal of physiology. Endocrinology and metabolism, 311(2), E302-E309 (2016-06-02)
Glucagon is a metabolically important hormone, but many aspects of its physiology remain obscure, because glucagon secretion is difficult to measure in mice and rats due to methodological inadequacies. Here, we introduce and validate a low-volume, enzyme-linked immunosorbent glucagon assay
Rune Ehrenreich Kuhre et al.
Journal of molecular endocrinology, 56(3), 201-211 (2016-01-29)
GLUTag, NCI-H716, and STC-1 are cell lines that are widely used to study mechanisms underlying secretion of glucagon-like peptide-1 (GLP-1), but the extent to which they resemble native L-cells is unknown. We used validated immunoassays for 14 different hormones to
Yang He et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(47), 19078-19083 (2011-11-02)
Human serum albumin (HSA) is widely used in clinical and cell culture applications. Conventional production of HSA from human blood is limited by the availability of blood donation and the high risk of viral transmission from donors. Here, we report
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