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D-015

Supelco

Diphenhydramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C17H22ClNO
CAS Number:
147-24-0
Molecular Weight:
291.82
EC Number:
200-659-6
MDL number:
MFCD00012479
UNSPSC Code:
41116107
PubChem Substance ID:
329798588
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Related Categories

General description

Diphenhydramine is an antihistamine sold over the counter under the trade name Benadryl® and in other over the counter medications such as Tylenol PM, Advil PM, and Excedrin PM. Dihydramine is also consumed recreationally as a euphoriant and a deliriant.

Application


  • Hepatoprotective effects of polyphenols: Studies on the hepatoprotective effects of polyphenol-enriched fractions against oxidative stress in Acetaminophen-induced liver injury incorporate the analysis of Acetaminophen Related Compound D. This research underscores its relevance in pharmacology and toxicology, providing a deeper understanding of drug-induced liver injuries and potential therapeutic approaches (Wu et al., 2017).


Legal Information

Benadryl is a registered trademark of Johnson & Johnson
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chang-Ik Choi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 909, 65-69 (2012-11-17)
Tamsulosin, a selective α₁-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH). We developed and validated a rapid, sensitive, and simplified liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the determination of tamsulosin in human
Andreas Papassotiropoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), E4369-E4374 (2013-10-23)
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point
Don W Coulter et al.
Anti-cancer drugs, 24(4), 415-421 (2013-01-19)
A pediatric study has established a maximum tolerated dose (MTD) for temsirolimus (Tem) of more than 150 mg/m intravenously/week. A phase I trial was conducted to establish the MTD for Tem in combination with valproic acid (VPA) in children and
Paige M Evans et al.
American journal of veterinary research, 73(12), 1983-1986 (2012-11-28)
To evaluate the effects of oral administration of diphenhydramine on pupil diameter, intraocular pressure (IOP), tear production, tear film quality, corneal sensitivity, and conjunctival goblet cell density (GCD) in clinically normal adult dogs. 12 healthy adult dogs. All dogs received
Edward Topp et al.
The Science of the total environment, 439, 136-140 (2012-10-16)
The widely used antihistamine diphenhydramine is present in municipal biosolids, and is detected in runoff from agricultural land fertilized with biosolids. In the present study the kinetics and major pathways of diphenhydramine dissipation in a loam, sandy loam, and clay
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