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252069

Sigma-Aldrich

Chlorodifluoroacetic anhydride

98%

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About This Item

Linear Formula:
(ClCF2CO)2O
CAS Number:
2834-23-3
Molecular Weight:
242.94
EC Number:
220-603-4
MDL number:
MFCD00000774
UNSPSC Code:
12352100
PubChem Substance ID:
24855179
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.347 (lit.)

bp

96-97 °C (lit.)

density

1.395 g/mL at 25 °C (lit.)

SMILES string

FC(F)(Cl)C(=O)OC(=O)C(F)(F)Cl

InChI

1S/C4Cl2F4O3/c5-3(7,8)1(11)13-2(12)4(6,9)10

InChI key

VBJIFLOSOQGDRZ-UHFFFAOYSA-N

General description

Photolysis of the vapour of chlorodifluoroacetic anhydride has been studied over the range 19-201°C using 248nm radiation.

Application

Chlorodifluoroacetic anhydride has been used:
  • for dual element acetylation tagging derivatization of amines by using microwave sustained helium emission detector
  • as derivatization reagent in determination of estrone and 17β-estradiol in hair by GC-MS

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H301,H312,H314

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Multi-element taggant and dual homolog derivatization concepts in GC/MED.
Hagen DF, et al.
Spectrochimica Acta. Part B: Atomic Spectroscopy, 40(1), 335-347 (1985)
Photochemistry of anhydrides. Part 6.-Photolysis of chlorodifluoroacetic anhydride,(CF 2 ClCO) 2 O.
Watkins PE and Whittle E.
J. Chem. Soc., Faraday, 80(8), 2323-2329 (1984)
M H Choi et al.
The Analyst, 125(4), 711-714 (2000-07-13)
An efficient procedure is described for the determination of estrone and 17 beta-estradiol in hair by gas chromatography-mass spectrometry (GC-MS). The method involves alkyloxycarbonylation with isobutyl chloroformate (isoBCF) of phenolic hydroxy groups after alkaline digestion of hair samples. The resulting
Courtney T Jollymore-Hughes et al.
Bioorganic & medicinal chemistry, 24(21), 5270-5279 (2016-09-18)
Association of cholinesterase with β-amyloid plaques and tau neurofibrillary tangles in Alzheimer's disease offers an opportunity to detect disease pathology during life. Achieving this requires development of radiolabelled cholinesterase ligands with high enzyme affinity. Various fluorinated acetophenone derivatives bind to

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