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  • Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.

Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.

The EMBO journal (2017-08-06)
Julien Brustel, Nina Kirstein, Fanny Izard, Charlotte Grimaud, Paulina Prorok, Christelle Cayrou, Gunnar Schotta, Alhassan F Abdelsamie, Jérôme Déjardin, Marcel Méchali, Giuseppe Baldacci, Claude Sardet, Jean-Charles Cadoret, Aloys Schepers, Eric Julien
PMID28778956
ABSTRACT

Among other targets, the protein lysine methyltransferase PR-Set7 induces histone H4 lysine 20 monomethylation (H4K20me1), which is the substrate for further methylation by the Suv4-20h methyltransferase. Although these enzymes have been implicated in control of replication origins, the specific contribution of H4K20 methylation to DNA replication remains unclear. Here, we show that H4K20 mutation in mammalian cells, unlike in