A catalyst for efficient and highly enantioselective hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones

A catalyst for efficient and highly enantioselective hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones

Organic letters (2001-01-11)

Burk, Hems, Herzberg, Malan, Zanotti-Gerosa

ABSTRACT

PhanePhos-ruthenium-diamine complexes catalyze the asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and alpha, beta-unsaturated ketones with high activity and excellent enantioselectivity.

MATERIALS

Product Number

Brand

Product Description

682144

Sigma-Aldrich

(R)-(–)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane, 96%

682292

Sigma-Aldrich

(S)-(+)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane, 90%

682306

Sigma-Aldrich

(R)-(–)-4,12-Bis[di(3,5-xylyl)phosphino]-[2.2]-paracyclophane, 95%

682136

Sigma-Aldrich

(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane, 96%