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  • Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells.

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells.

Scientific reports (2016-02-26)
Mikko Konki, Kalyan Pasumarthy, Maia Malonzo, Annele Sainio, Cristina Valensisi, Mirva Söderström, Maheswara Reddy Emani, Aki Stubb, Elisa Närvä, Bishwa Ghimire, Asta Laiho, Hannu Järveläinen, Riitta Lahesmaa, Harri Lähdesmäki, R David Hawkins, Riikka J Lund
PMID26911679
ABSTRACT

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key regulator of oxidative stress and DNA damage control in abnormal cells. Our findings provide novel insight into the mechanisms associated with spontaneous transformation of human pluripotent stem cells towards malignant fate. The same mechanisms may control the genomic stability of cells in somatic tissues.