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  • Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma.

Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma.

Fitoterapia (2009-05-19)
Manjuan Liu, David R Katerere, Alexander I Gray, Véronique Seidel
ABSTRACT

Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2alpha, 3beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf. The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.

MATERIALS
Product Number
Brand
Product Description

Supelco
Punicalagin, analytical standard
Sigma-Aldrich
Punicalagin, ≥98% (HPLC), from pomegranate