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Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1.

Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1.

Organic & biomolecular chemistry (2009-03-06)

David Foley, Patrick Bailey, Myrtani Pieri, David Meredith

ABSTRACT

Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.

MATERIALS

Product Number

Brand

Product Description

Supelco

Nabumetone, analytical standard

Nabumetone, European Pharmacopoeia (EP) Reference Standard