Antitubercular constituents from the stem wood of Cinnamomum kotoense.

Antitubercular constituents from the stem wood of Cinnamomum kotoense.

Journal of natural products (2005-09-27)

Fu-Chi Chen, Chien-Fang Peng, Ian-Lih Tsai, Ih-Sheng Chen

ABSTRACT

Five new compounds, kotolactone A (1), kotolactone B (2), secokotomolide (3), kotodiol (4), and 2-acetyl-5-dodecylfuran (5), and 36 known compounds have been isolated from the stem wood of Cinnamomum kotoense. The structures of these new compounds were determined by means of spectroscopic analysis. The known butanolides, isoobtusilactone A (6) and lincomolide B (7), showed in vitro antitubercular activities with MIC values of 22.48 and 10.16 microM, respectively, against Mycobacterium tuberculosis 90-221387.

MATERIALS

Product Number

Brand

Product Description

73983

Supelco

Mettler-Toledo Calibration substance ME 18555, Benzoic acid, analytical standard, (for the calibration of the melting point system), traceable to primary standards (LGC)

427608

Sigma-Aldrich

Benzoic acid, purified by sublimation, ≥99%

77634

Supelco

Mettler-Toledo Calibration substance ME 51143093, Vanillin, traceable to primary standards (LGC)

W398403

Sigma-Aldrich

4-Hydroxybenzaldehyde, ≥97%, FG

33047

Sigma-Aldrich

Benzoic acid, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9% (alkalimetric)