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  • Nickel-catalyzed C-O activation of phenol derivatives with potassium heteroaryltrifluoroborates.

Nickel-catalyzed C-O activation of phenol derivatives with potassium heteroaryltrifluoroborates.

Organic letters (2010-08-19)
Gary A Molander, Floriane Beaumard
ABSTRACT

A general method based on nickel-catalyzed C-O activation of various phenol derivatives with potassium (hetero)aryltrifluoroborates has been developed. A large number of heterobiaryls can be easily obtained with yields up to 99% using methanesulfonate cross-coupling partners.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium 2-bromo-4-(trifluoromethyl)pyridine-3-trifluoroborate