M9269
IgG1, Kappa from murine myeloma
clone MOPC 21, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Mouse IgG1-κ
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
MOPC 21, monoclonal
form
buffered aqueous solution
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Looking for similar products? Visit Product Comparison Guide
Specificity
Specificity is determined by mouse monoclonal isotyping strips. The purified immunoglobulin preparation is non-reactive with anti mouse IgA, IgM, IgG2a, IgG2b or IgG3
Application
IgG1, κ from murine myeloma has been used in:
- the in situ hybridization experiments with bulbar conjunctiva sections
- immunohistochemistry of cattle and artery tissues
IgG1, κ from murine myeloma has been used:
- in immunofluorescence of leukocytes at a concentration of 50 μg/ml
- as a standard in enzyme linked immunosorbent assay (ELISA)
- as exchange antibody in centrifugal gel filtration
IgG1, Kappa from murine myeloma has been used in flow cytometric analysis and immunoprecipitation.
Biochem/physiol Actions
IgG antibody subtype is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
IgG1 has a molecular weight of 146 kDa and is an abundantly expressed IgG subclass. IgG1 deficiencies contribute to overall decrease in total IgG levels resulting in hypogammaglobulinemia. IgG1 promotes bacterial phagocytosis and mediates vaccine-induced protection from infection. The ratio of IgG2a to IgG1 is crucial for the immune response against Leishmania tropica infection. It has high binding affinity towards the Fcγ receptors (FcγR). High levels of IgG1-κ antibodies is associated with the pathology of glomerulonephritis.
Physical form
Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide
Storage and Stability
Store at −20 °C. The product may be stored frozen in working aliquots at −20 °C. Repeated freezing and thawing is not recommended.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Visceral tissue growth and proliferation during the bovine lactation cycle.
Baldwin RL, et al.
Journal of Dairy Science, 87(9), 2977-2986 (2004)
M Dellian et al.
British journal of cancer, 82(9), 1513-1518 (2000-05-02)
Molecular charge is one of the main determinants of transvascular transport. There are, however, no data available on the effect of molecular charge on microvascular permeability of macromolecules in solid tumours. To this end, we measured tumour microvascular permeability to
The relative contribution of mast cell subsets to conjunctival TH2-like cytokines.
Anderson DF, et al.
Investigative Ophthalmology & Visual Science, 42(5), 995-1001 (2001)
Elin Borgen et al.
Breast cancer research : BCR, 20(1), 120-120 (2018-10-17)
The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies of
B Steppich et al.
American journal of physiology. Cell physiology, 279(3), C578-C586 (2000-08-16)
Strenuous, anaerobic exercise leads to an increase of leukocytes that are mobilized from the marginal pool. We have analyzed in human peripheral blood the effect of exercise on the number of CD14(+)CD16(+) monocytes as determined by two-color immunofluorescence and flow
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service