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Merck

ZAK

Synonyms:
AZK, MLK7, MLT, MLTK, MRK, mlklak, pk
Species:
Human ZAK (51776), Mouse Zak (65964), Rat Zak (311743), chicken ZAK (424149), dog ZAK (478802), cow ZAK (519251)
UniProtKB ID:
Gene ID:
  • Human(51776) Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(65964) sterile alpha motif and leucine zipper containing kinase AZK
  • Rat(311743) sterile alpha motif and leucine zipper containing kinase AZK
  • chicken(424149) sterile alpha motif and leucine zipper containing kinase AZK
  • dog(478802) sterile alpha motif and leucine zipper containing kinase AZK
  • cow(519251) sterile alpha motif and leucine zipper containing kinase AZK

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Proteins

Product Number
Description
Species
SRP5101
ZAK, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human